r-Hirudin for percutaneous coronary interventions—time to reconsider?
نویسندگان
چکیده
منابع مشابه
Generation of anti-hirudin antibodies in heparin-induced thrombocytopenic patients treated with r-hirudin.
BACKGROUND Hirudin is a small protein with strong thrombin inhibition that may be antigenic. The generation and disappearance of anti-hirudin antibodies were investigated in patients with heparin-induced thrombocytopenia who were treated with recombinant hirudin (r-hirudin) for >/=5 days. METHODS AND RESULTS The IgA, IgE, IgG, and IgM isotypes of anti-hirudin antibodies were determined by ELI...
متن کاملEfficacy of hirudin in reducing cardiovascular events in patients with acute coronary syndrome undergoing early percutaneous coronary intervention.
AIMS Although hirudin is superior to unfractionated heparin for prevention of death, myocardial infarction, or refractory ischaemia in patients with non-ST-elevation acute coronary syndrome, it is not clear whether hirudin is also of benefit in acute coronary syndrome patients undergoing early percutaneous coronary intervention. METHODS AND RESULTS In the OASIS 2 trial, 10 141 patients with n...
متن کاملTreatment of an acute flush reaction caused by subcutaneous r-hirudin with pegylated hirudin.
We report a patient who was treated with recombinant (r)-hirudin for heparin-induced thrombocytopenia and developed a flush reaction twice upon re-exposure to 25 mg of subcutaneous r-hirudin. Antihirudin IgG antibodies developed. The patient received 50 mg of PEG-hirudin subcutaneously over 2 days. No side-effects occurred. The level of IgG antihirudin antibodies increased. Ecarin clotting time...
متن کاملPercutaneous Coronary Intervention for Bifurcation Coronary Disease
Correspondence to: Dr Yves Louvard, Institut Cardiovasculaire Paris Sud, Institut Hospitalier Jacques Cartier, 6 avenue du Noyer Lambert, 91300 Massy, France; [email protected] _________________________ E ver since coronary angioplasty was first undertaken, treatment of coronary bifurcation lesions has posed technical problems. w2 Specific difficulties involving access to the side branch an...
متن کاملAntibiotic prophylaxis for endocarditis: time to reconsider.
Some cardiac conditions require antibiotic prophylaxis for some types of dental treatment to reduce the risk of infective endocarditis (IE). All medical and dental practitioners are familiar with this practice but tend to use different regimens in apparently similar circumstances. Generally, the trend has been to prescribe antibiotics if in doubt. This review explores the evidence for antibioti...
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2002
ISSN: 0195-668X
DOI: 10.1053/euhj.2001.2826